Cisplatin hydrolysis
WebCisplatin is a potent and valuable chemotherapy agent used to treat a broad spectrum of malignancies. Renal tubular dysfunction and a cumulative impairment in kidney function, … WebChemical basis for the detoxification of cisplatin-derived hydrolysis products by sodium thiosulfate Cisplatin remains the most widely used platinum-based anti-cancer drug and is included on the World Health Organization's list of essential medicines.
Cisplatin hydrolysis
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WebInside the cell, the neutral cisplatin molecule undergoes hydrolysis, in which a chlorine ligand is replaced by a molecule of water, generating a positively charged species, as shown below and in Figure 1. Hydrolysis occurs inside the cell due to a much lower … WebKinetics of the adduct formation of cisplatin and its hydrolysis products with 5′-GMP was investigated using capillary electrophoresis (CE) under ‘simulated physiological conditions’. Therefore, chloride ion and phosphate concentration as well as the pH were chosen comparable to intracellular conditions.
WebMay 1, 2024 · Abstract. The discovery of the antitumor activity of cisplatin in 1969 has accelerated research in platinum chemistry. In particular, cisplatin hydrolysis, the rate-determining process activating ... WebJan 11, 2024 · This information will help you hydrate yourself after getting high-dose cisplatin chemotherapy. Cisplatin can affect your kidneys. To keep your kidneys from …
Webcis-Dichlorodiammineplatinum(II). Acid Hydrolysis and Isotopic Exchange of the Chloride Ligands1 John W. Reishus and Don S. Martin Jr. Cite this: J. Am. Chem. Soc.1961, 83, 11, 2457–2462 Publication Date(Print):June 1, 1961 Publication History Publishedonline1 May 2002 Publishedinissue1 June 1961 … WebThe cisplatin hydrolysis products are more toxic than the parent drug itself. Sodium thiosulfate was successfully used to reduce toxic side effects of cisplatin hydrolysis products [7]. Because of the severe side effects, cisplatin is administrated in small doses at low concentrations. For these reasons,
WebCisplatin, cis - [PtCl 2 (NH 3) 2 ], is extensively used for the treatment of testicular and ovarian cancers and increasingly against other types of solid tumors (head/neck, lung, cervical, and bladder) ( 1 , 2 , 3 , 4 ). The cytotoxic effect of cisplatin is thought to be due to attack on DNA bases and induction of apoptosis in cancer cells ( 5 , 6
WebNov 17, 2024 · The anticancer drug cis-platin hydrolyzes in water with a rate constant of 1.5 × 10−3 min−1 at pH 7.0 and 25°C. Calculate the half-life for the hydrolysis reaction under these conditions. If a freshly prepared solution of cis-platin has a concentration of 0.053 M, what will be the concentration of cis-platin after 5 halflives? after 10 half-lives? bkl front tourWebA stable, microcrystalline form of cisplatin, a process for its preparation, and stable, sterile dry-mix formulations thereof which are more rapidly reconstituted with sterile water to produce solutions suitable for intravenous administration to man than are similar formulations containing "regular" cisplatin. The microcrystalline cisplatin and dry-mix … daughter in romanianWebCisplatin Injection is a sterile, multidose vial without preservatives. Store at 15° to 25°C (59° to 77°F). Do not refrigerate. Protect unopened container from light. The cisplatin … bkl electric pressure fryer fkmfcWebFeb 28, 2024 · One of the main problems in chemotherapy using platinum drugs as anticancer agents is the resistance phenomenon. Synthesizing and evaluating valid alternative compounds is challenging. This review focuses on the last two years of progress in the studies of platinum (II)- and platinum (IV)-based anticancer complexes. In … daughter in other languagesWebSep 21, 2010 · Cisplatin, or cis- [Pt (NH (3)) (2)Cl (2)], was the first member of a new revolutionary class of anticancer drugs that is still used today for the treatment of a wide variety of cancers. The mode... daughter in mother\\u0027s wedding dress photoWebDec 15, 2015 · f-MWCNT-2 contains ester linkage, which has also been commonly used to facilitate controlled release of drug molecules from nanocarriers or prodrugs upon hydrolysis. 41 On the other hand, disulfide bond containing linkers were also included to attach AuNPs on MWCNTs open-tips. Disulfide linkage is widely known to be sensitive to … bklg services pty lWebSep 21, 2010 · Cisplatin, or cis-[Pt(NH(3))(2)Cl(2)], was the first member of a new revolutionary class of anticancer drugs that is still used today for the treatment of … daughter in russian translation