Gpx4 metastasis
WebDec 23, 2024 · Glutathione peroxidase 4 (GPX4) is a main regulator of ferroptosis, which is pivotal for TNBC cell growth. We investigated GPX4-mediated ferroptosis in gefitinib sensitivity in TNBC. Gefitinib resistant TNBC cells MDA-MB-231/Gef and HS578T/Gef were constructed and treated with lentivirus sh-GPX4 and ferroptosis inhibitor ferrostatin-1. WebDec 11, 2024 · GPX4 is a prognostic marker in human PDAC Our animal studies indicate that GPX4 may play a tumor suppressor-like role, whereas TMEM173 may have an oncogenic-like role in pancreatic...
Gpx4 metastasis
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WebSep 26, 2024 · GPX4 inhibitor was found to augment the anticancer effect of platinum drugs in lung cancer BM, providing novel strategies for lung cancer patients with BM. 1 … WebApr 10, 2024 · Moreover, high RUNX1-IT1 was linked to poor prognosis, and a strong positive correlation between RUNX1-IT1 and GPX4 was observed in clinical breast cancer tissues. Taken together, our data reveal that RUNX1-IT1 promotes breast cancer carcinogenesis through blocking ferroptosis via elevating GPX4, targeting of the …
WebApr 14, 2024 · GPX4 is the only peroxidase known to efficiently reduce esterified, hydroperoxy fatty acids into unreactive alcohols 8. Recently, ferroptosis suppressor protein 1 (FSP1) was identified as a... WebAug 20, 2024 · GPX4 converts glutathione into oxidized glutathione (GSSG) concomitantly reducing the cytotoxic lipid peroxides (L-OOH) to the corresponding alcohols (L-OH; …
WebBlood and lymph are two main pathways of tumor metastasis; however, hematogenous metastasis and lymphatic metastasis are difficult to inhibit simultaneously. ... (AA) and the GPX4 inhibitor RSL3, which could not only induce ferroptosis but also alleviate ferroptosis resistance. As a result, DA/RSL3 effectively triggered ferroptosis in tumor ... WebApr 6, 2024 · The prognosis of patients with high GPX4 expression was worse than that of patients with low GPX4 expression, and OS (overall survival) was significantly shorter for patients with high expression ...
WebNov 23, 2024 · Summary. Encouraged by the dependence of drug-resistant, metastatic cancers on GPX4, we examined biophysical mechanisms of GPX4 inhibition, which …
WebSep 26, 2024 · Results. The derivative brain metastatic subpopulations (PC9‐BrMs) of parental cells PC9 developed obvious resistance to platinum. Radically altered profiles of … corrosion of conformity vinylWebMay 12, 2024 · Glutathione peroxidase 4 (GPX4) is one of the most important antioxidant enzymes. As the key regulator of ferroptosis, GPX4 has attracted considerable attention in the fields of cancer, cardiovascular, and neuroscience research in the past 10 years. How to regulate GPX4 activity has become a hot topic nowadays. corrosion of electronic resistorsWebFeb 8, 2024 · Mechanically, GPX4 inhibited GRHL3 expression by binding to the promoter of this gene with peptide which is constituted by 45-115 amino acid located in the N-terminal … corrosion of conformity song live volumneWebBesides, ACSL4 expression, GPX4 expression, and their combination status were independent prognostic factors for disease-free survival. Analyses of the Kaplan-Meier Plotter database suggested that higher ACSL4 expression is related to better overall survival, and higher GPX4 expression is related to better distant metastasis-free survival. corrosion of copper pipes by waterWebApr 14, 2024 · Thiol-containing tripeptide glutathione (GSH) is not only the main antioxidant in mammalian cells, but also the primary substrate of GPX4. When glutathione deficiency or GPX4 activity decreased, the antioxidant capacity of cells decreased, resulting in lipid peroxidation and metabolic dysfunction. corrosion of iron labWebNov 12, 2024 · We hypothesized that CST1 could regulate gastric cancer progression by regulating GPX4 and ferroptosis. Whole transcriptome sequencing suggested that the … corrosion offshore wind asiaWebNov 1, 2024 · A, Glutathione (GSH) and thioredoxin (TRX red) are redox buffers that are used by antioxidant enzymes such as superoxide dismutase (SOD), peroxiredoxin (PRDX), and glutathione peroxidase 4 (GPX4) to neutralize ROS, including O 2−, H 2 … corrosion of glass