Phospho-acss2

Author: nnoy

August undefined, 2024

WebJul 7, 2024 · Acetyl-CoA synthetase 2 (ACSS2) is a crucial member of the acetyl-CoA synthetase (ACSS) family and is transcribed from the ACSS2 gene. The ACSS2 gene, first isolated from yeast cells, encodes two isoforms produced by alternative transcription start site selection, with lengths of 1606 bp and 2106 bp [ 8 ]. WebNov 12, 2024 · ACSS2 is the only known enzyme that can recycle acetate derived from deacetylation reactions in the cytoplasm and nucleus of cells, including both protein and metabolite deacetylation reactions. As such, ACSS2 can recycle acetate derived from histone deacetylase reactions as well as protein deacetylation reactions mediated by …

Phospholipase A2 - an overview ScienceDirect Topics

WebSep 15, 2024 · The invention relates to novel compositions, combinations and methods relating to compounds which inhibit EZH2 and their uses for treating and/or preventing tumors associated with methyltransferase EZH2. More specifically the invention relates to synergistic bi-therapy compositions for use in a method of treating and/or preventing … WebMar 8, 2024 · Influenza virus is responsible for respiratory diseases that can be severe or even lethal, especially in young children and the elderly 1.The virus causes annual … chine thybaud actrice

Glucose-derived acetate and ACSS2 as key players in …

WebIn the nucleus, ACSS2 binds to transcription factor EB and translocates to lysosomal and autophagy gene promoter regions, where ACSS2 incorporates acetate generated from … WebMar 1, 2024 · The standard compounds, including pyruvate, lactate, alanine, acetate, succinate, glucose, palmitate, glycine, glutamate, isoleucine, valine, leucine, and … WebDeacetylates ACSS2 leading to its activation, and HMGCS1. Involved in liver and muscle metabolism. ... All lanes : Anti-SIRT1 (phospho T530) antibody [EPNCIR153] (ab156585) at 1/1000 dilution Lane 1 : 293T cell lysates Lane 2 : 293T cell lysates treated with Calyculin A Lysates/proteins at 10 µg per lane. Secondary chinet heavy-duty paper plates

Frontiers Acetate Revisited: A Key Biomolecule at the Nexus of ...

Anti-ACSS2 Antibody (A-9) SCBT - Santa Cruz Biotechnology

WebAcss2 −/ mice fed a chow diet (SI Appendix, Fig. S3 A–C). Taken together, these results indicate that the absence of ACSS2 im-pedes fat deposition and obesity associated with high dietary-fat intake. Acss2 Deletion Protects Against Hepatic Steatosis. Insulin resistance and hepatic steatosis are two common pathological phenotypes WebAutoantigen. PLA2R is a type I transmembrane receptor and is one of four members of the mammalian mannose receptor family. It is a 185-kDa protein expressed on, and confined … chine tiananmenWebJan 12, 2015 · ACSS2 exhibits copy-number gain in human breast tumors, and ACSS2 expression correlates with disease progression. These results signify a critical role for acetate consumption in the production of lipid biomass within the harsh tumor microenvironment. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights … chin ethnic myanmar

"WebNov 23, 2024 · ACSS2 enables cholesterol synthesis in the cytoplasm, which is trafficked to the surface to provide mechanical tenacity. GM3-IRE1-sXBP1-ACSS2-cholesterol axis is … " - Phospho-acss2

Phospho-acss2

(orb1096966) ACSS2(Phospho-Ser659) Antibody - Biorbyt - CiteAb

Web(orb1096966) ACSS2 (Phospho-Ser659) Antibody Sign in or register to save this reagent to your favourites Supplier Biorbyt Host Rabbit Type Primary Clonality Polyclonal Conjugate …

Did you know?

WebMay 31, 2024 · ACSS2 seems to bind to the promoters of immediate early genes before memory consolidation, implying that acetate, rather than ACSS2, is the limiting factor for histone acetylation at these genes. WebACSS2 Antibodies. Santa Cruz Biotechnology, Inc. offers a broad range of ACSS2 antibodies. Select ACSS2 antibodies from monoclonal antibodies listed below. View …

WebMar 1, 2024 · VY-3-135 is a potent, stable ACSS2 inhibitor with good bioavailability. (A) Schematic of the forward reaction catalyzed by ACSS2. (B-C) Chemical structures of VY-3-249 and VY-3-135 and IC50 determinations for inhibitors against ACSS1 (blue squares) and ACSS2 (red circles). Data points represent mean (filled shapes) and replicates (empty … WebSep 18, 2024 · Acetyl-CoA synthetase 2 (ACSS2) is a conserved nucleocytosolic enzyme that converts acetate to acetyl-CoA. Adult mice lacking ACSS2 appear phenotypically normal but exhibit reduced tumor burdens in mouse models of liver cancer. The normal physiological functions of this alternate pathway of acetyl-CoA synthesis remain unclear, …

WebImportantly, we show that ACSS2 Ser-267 phosphorylation regulates its stability by reducing polyubiquitination and degradation. ACSS2 Ser-267 is critical for OGT-mediated GBM … WebPhospho (6) Supplier US Biological (50) Biorbyt (48) LSBio (39) Aviva Systems Biology (12) antibodies-online (12) ABclonal (2) Abbexa (9) Abbkine (1) Abcam (5) Abgent (2) ... Anti-ACSS2 antibody produced in rabbit. HPA004141 is a primary antibody from MilliporeSigma. 3 Citations Host: Rabbit Clonality: Polyclonal Validations: None Available

WebNational Center for Biotechnology Information

WebMar 21, 2024 · ACSS2 (Acyl-CoA Synthetase Short Chain Family Member 2) is a Protein Coding gene. Diseases associated with ACSS2 include Orofacial Cleft 1 and … chinet dome coffee lidWebTreatment with biguanides, but not isotretinoin, significantly upregulated ACSS2 gene expression in primary sebocytes and showed synergism with lipogenic activators to induce DNL genes. ... Phospho-mTOR signals were determined by absorbance at 450nm using a SpectraMax iD3 plate reader (Molecular Devices, San Jose, CA). Statistical Analysis. chin ethnicity myanmarWebACSS2 / ACAS2 is a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. The protein acts as a monomer and produces acetyl-CoA from acetate in a reaction that requires ATP. Expression of this gene is regulated by sterol regulatory element-binding proteins, transcription factors that activate ... granger catholic churchWebDownload scientific diagram Targeting OGT or CDKs blocks GBM growth ex vivo a Representative images depicting tumor growth in organotypic brain slices derived from mice intracranially injected ... chine tibet carteWebJan 21, 2024 · We interrogate whether ACSS2 can facilitate the local transfer of acetyl groups. Our results point to direct transfer of intact acetate that is mediated by ACSS2, underscoring a critical function of acetate transfer in using local and nuclear acetate pools for histone acetylation and rapid transcriptional activation. granger car insurance agencyWebProduct Name ACSS2(Phospho-Ser659) Antibody; Host Species Rabbit; Clonality Polyclonal; Isotype IgG; Applications WB; Species Reactivity Hu Ms; Immunogen Description The … chinet lunch costcoWebJun 11, 2024 · Abstract. Autophagy is an intracellular degenerative pathway which is responsible for neuronal survival. Under the condition of nutrient deprivation, autophagy can lead to dysfunction in memory consolidation. … chine tibet